产品货号：
Z34353
中文名称：
TDT/DNTT抗体
英文名称：
Anti-TDT/DNTT Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TDT/DNTT Antibody |
| 指标别名 | DNA nucleotidylexotransferase;DNTT;TDT;Terminal addition enzyme;Terminal transferase |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | DNTT |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human TDT Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. |
| 实际分子量 | 59KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Terminal Deoxynucleotidyl Transferase,also known as TDT and terminal transferase,is a unique DNA polymerase without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers.Its gene is mapped to the region 10q23-q24.And TDT cDNA contains an open reading frame of 1,530 basepairs corresponding to a protein containing 510 amino acids.TDT may be responsible for inserting nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes.The enzyme is present in immature thymocytes,some bone marrow cells,transformed pre-B and pre-T cell lines,and leukemia cells.Additionally,TDT catalyses the addition of nucleotides to the 3' terminus of a DNA molecule.Unlike most DNA polymerases it does not require a template.The preferred substrate of this enzyme is a 3'-overhang,but it can also add nucleotides to blunt or recessed 3' ends.Cobalt is a necessary cofactor. |
| Uniprot ID | P04053 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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